Publications

The following is a list of recent publications that describe the microfluidic technologies underpinning the FPC@DCU, which have been developed under a number of research programmes prior to its establishment, in particular the SFI-funded Biomedical Diagnostics Institute (BDI).

Keywords:

Lab-on-a-Disc (LoaD)

PhosphaSense: A fully integrated, portable lab-on-a-disc device for phosphate determination in water. Sensors & Actuators B – Chemical, 246:1085–1091, July 2017, DOI:10.1016/j.snb.2016.12.040.

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Development of a system for on-disc isothermal amplification and detection of bacterial RNA. Sensors & Actuators B – Chemical, 239:235–242, February 2017, DOI:10.1016/j.snb.2016.08.018.

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Baking powder actuated centrifugo-pneumatic valving for automation of multi-step bioassays. Micromachines, 7(10):175–184, 2016, DOI:10.3390/mi7100175.​

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CD-based microfluidics for primary care in extreme point-of-care settings? Micromachines, 7(2):22–32, 2016, DOI:10.3390/mi7020022.

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Rapid, culture-independent, optical diagnostics of centrifugally captured bacteria from urine samples. Biomicrofluidics, 9(4):044118, 2015, DOI:10.1063/1.4928070.

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Label-free electrochemical impedance detection of cancer cells from whole blood on an integrated centrifugal microfluidic platform. Biosensors & Bioelectronics, 68:382–389, 2015, DOI:10.1016/j.bios.2014.12.049.

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Paper imbibition for timing of multi-step liquid handling protocols on event-triggered centrifugal microfluidic lab-on-a-disc platforms. RSC Advances, 5(3):1818–1826, 2015, DOI:10.1039/C4RA14887H.

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Lab-in-a-Trench (LiaT)

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Real-time monitoring of cell migration, phagocytosis and cell surface receptor dynamics using a novel, live-cell opto-microfluidic technique. Analytica Chimica Acta, 872:95–99, 2015, DOI:10.1016/j.aca.2014.12.035.

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Cell Sorting

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Quantitative distribution and cluster sizing of CTC events from a blood sample using a size exclusion centrifugal rail.Nature Microsystems & Nanoengineering, 1:15018, 2015, DOI:10.1038/micronano.2015.18.

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Single Cell Analysis


Living photonics (LiPhos) single cell analysis – Label free detection methods. Acta Physiologica, 215(706):32–33, September 2015, DOI:10.1111/apha.12602.​

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An integrated centrifugo-opto-microfluidic platform for arraying, analysis, identification and manipulation of individual cells. Lab on a Chip, 15(2):378–381, 2015, DOI:10.1039/c4lc01002g.​

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Rapid and cost-efficient enumeration of rare cancer cells from whole blood by low-loss centrifugo-magnetophoretic purification under stopped-flow conditions. Cytometry Part A, 87(1):74–80, 2015, DOI:10.1002/cyto.a.22588.

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Surface Modification

Polyethylene imine/graphene oxide layer-by-layer surface functionalization for significantly improved limit of detection and binding kinetics for immunoassays on acrylate surfaces. Colloids & Interfaces B: Biointerfaces, 2017. 

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Fabrication

New strategies for stationary phase integration within centrifugal microfluidic platforms for applications in sample preparation and pre-concentration. Analytical Methods, 9(13):1998–2006, 2017, DOI:10.1039/C7AY00127D.

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Measurement Accuracy

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Fully automated chemiluminescence detection using the electrified-Lab-on-a-Disc (eLoaD) platform. Lab on a Chip, 16(20):4002–4011, 2016, DOI:10.1039/C6LC00973E.

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Integrated micromixer for incubation and separation of cancer cells on a centrifugal platform using inertial and Dean forces. Microfluidics & Nanofluidics, 18(3):513–526, 2015, DOI:10.1007/s10404-014-1450-7.

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Utilising the microfluidic lab-in-a-trench platform to enable single cell level drug screening of hepatocytes.Acta Physiologica, 215(706):96, September 2015, DOI:10.1111/apha.12603.

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